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EAST PALESTINE, Ohio (AP) — A freight train derailment in Ohio near the Pennsylvania state line left a mangled and charred mass of boxcars and flames Saturday as authorities launched a federal investigation and monitored air quality from the various hazardous chemicals in the train.

About 50 cars derailed in East Palestine at about 9 p.m. EST Friday as a train was carrying a variety of products from Madison, Illinois, to Conway, Pennsylvania, rail operator Norfolk Southern said Saturday. There was no immediate information about what caused the derailment. No injuries or damage to structures were reported.

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“The post-derailment fire spanned about the length of the derailed train cars,” Michael Graham, a member of the National Transportation Safety Board, told reporters Saturday evening. “The fire has since reduced in intensity, but remains active and the two main tracks are still blocked.”

Norfolk Southern said 20 of the more than 100 cars were classified as carrying hazardous materials — defined as cargo that could pose any kind of danger “including flammables, combustibles, or environmental risks.” Graham said 14 cars carrying vinyl chloride were involved in the derailment “and have been exposed to fire,” and at least one “is intermittently releasing the contents of the car through a pressure release device as designed.”

“At this time we are working to verify which hazardous materials cars, if any, have been breached,” he said. The Environmental Protection Agency and Norfolk Southern were continuing to monitor air quality, and investigators would begin their on-scene work “once the scene is safe and secure,” he said.

Vinyl chloride, used to make the polyvinyl chloride hard plastic resin used in a variety of plastic products, is associated with increased risk of liver cancer and other cancers, according to the federal government’s National Cancer Institute. Federal officials said they were also concerned about other possibly hazardous materials.